Bench-Scale: Bioprocess Development, Optimization, & Derisking
MSUBI’s fermentation process development occurs in two separate, on-site laboratories at our Lansing facility. The process development lab has multiple bench tops and 22 small-scale fermentors—ranging from 2–10L—available for experiments. We also have a wet lab for media preparation and equipment cleaning. All of our fermentors are connected to systems that provide the most accurate, real-time monitoring and control of temperature, pH, gas flow, and agitation.
Bioprocessing and Fermentation
Our team has extensive experience working with a variety of organisms, including: bacteria, yeast, fungi, and heterotrophic algae. Moreover, we are able to grow these organisms in aerobic, anaerobic, or microaerobic conditions—whether they require batch, batch-fed, or continuous fermentations.
At MSUBI, our team works with you to propel your technology to commercial readiness. Our highly experienced team has a solid track-record improving bioprocesses and fermentations through many different means, including: optimizing process controls, process development, strain improvement, and media optimization. Further, our team has access to a variety of analytical equipment and expertise that is invaluable to scaling up your technology.
Pilot Plant Scale-up
MSUBI’s pilot plants replace the need for you to build your own. Here, our facility and extraordinary team serve as your very own bioprocess or chemical scale-up facility. We collaborate with you, helping to design the best plan for your innovation’s scale-up—including biomass processing, fermentation, separation, as well as purification & recovery.
Our three-level pilot facility, with a cargo elevator connecting each level, is equipped with modern equipment, instrumentation, and computer-based control systems. Our facility is plug-and-play: With a five-ton capacity ceiling crane, we can bring in necessary equipment to accelerate your technology.
Also on-site, MBI has two 3,800L fermentors, along with a 150L and a 200L unit–as well as four 10L bench-scale “satellite” units—used to diagnose scale-up effects. All process development and pilot plant fermentors have in-line mass spectrometer off-gas analysis and a complete suite of automated process control.
Application Testing and Product Development
Before your technology runs at commercial scale, MSUBI’s team has the ability to perform both application testing and product development batch runs, using our either of our 4,000L pilot plants as your intermediate production collaborator. Often times, our clients may not be ready to scale-up beyond 4,000L, but they still require product batches on a consistent basis. These batches are used to create product that is sent to buyers for application testing or validation; or for venture capital firms that are interested in technologies, yet need to vet both the process and the product.
Scale-Up Beyond MSUBI: Tech Transfer
Once we have successfully scaled your technology, our team is ready to assist in the transferring of your technology to your commercial partner. Adding value to our services, we will provide you with a complete data package during the transfer of your sustainable innovation.
With a technology transfer success rate of 100%, you can count on MSUBI’s understanding of the process. Transferring technologies from our 4,000L scale to a variety of commercial production facilities is what we do.
Our track record: Over the last five years alone, MSUBI has successfully scaled over 20 different technologies from bench-scale to pilot-scale with a remarkable 100% success rate. Some of our collaborators include: DuPont, Genomatica, Verdezyne, OPX BIO, Amyris, Novozymes, Marrone Bio Innovations, Metabolix, and Tepha Medical Devices.