MSU Bioeconomy Institute–Lansing delivers custom, collaborative solutions to scale fermentation and downstream processes from concept to commercialization. With decades of specialized experience and expertise across a diverse array of microbes—including yeast, fungi, algae, aerobic and anaerobic bacteria, and spore formers—we’ve successfully supported over 70 projects in the past 20 years. Our innovative team provides scalable bioprocesses and comprehensive data packages, empowering you to achieve commercial success. At MSUBI Lansing, your success is the true measure of ours.
Fermentation Development and Process Optimization
- Bench-scale reactors with maximum working volumes of 4x 1L, 4x 2L, 8x 3.5L, 9x 5L, and 8x 10L
- Extensive experience working with bacteria, yeast, fungi, and heterotrophic algae for diverse fermentation needs
- Flexibility to support both aerobic and anaerobic processes at all reactor scales
- Creative, client-focused solutions tailored to meet the specific needs of your project
Pilot Scale Fermentation
- Pilot-scale fermenters with working volumes of 2x 30L, 100L, 150L, 500L, and 3,000L to meet your scaling needs
- Advanced live off-gas measurement for real-time process insights and optimization
- Customizable fermentation software controls tailored to your specific project requirements.
- Proven capability of achieving >250 mmol/L/hr oxygen uptake rate (OUR) at the 3,000L scale
- Flexible fed-batch strategies, supporting multiple feed types and approaches for enhanced process adaptability
Tech Transfer and Data Package
- Real-time, continuous data collection captured every minute for precise monitoring
- Capture of over 80 unique data points ensures comprehensive process insights
- Live processing of off-gas, feed, and customizable inputs for accurate results
- Detailed digital batch records documenting materials and methods used
- Clients receive a complete, editable copy of all logged data and documentation for flexibility and ease of use
Downstream Processing and Product Recovery
- Two high-speed disc stack centrifuges
- Cell Disruption via homogenization
- Chromatographic Processes and Ion Exhchange
- Microfiltration, Ultrafiltration, and Nanofiltration (hollow fiber or spiral wound)
- Pfaudler Wiped Film Evaporator
- Forced Air Tray Dryers
- Solvent Extraction (bench scale)
- Lyophilization (bench scale)
Full Utilities Set-up for Rental DSP Equipment
- Rotary Drum Vacuum Filter
- Spray Dryer
- Centrifuges: Sedicanter, Nozzle Discharge, Tri-phase, Solid Bowl
- Cryogenic Pelletizer
- GEA Model R Filtration Pilot Skid
Analytical
- HPLC, UPLC, GC, GC/MS
- UV-Vis Spectroscopy
- YSI Biochemistry Analyzer
- Protein analysis
- Access to campus analytical equipment including HPLC/MS, NMR, and LC-MS/MS, ICP analysis